Stearoyl-CoA Desaturase-2 in Murine Development, Metabolism, and Disease
نویسندگان
چکیده
منابع مشابه
An Evolutionary Relationship Between Stearoyl-CoA Desaturase (SCD) Protein Sequences Involved in Fatty Acid Metabolism
Background: Stearoyl-CoA desaturase (SCD) is a key enzyme that converts saturated fatty acids (SFAs) to monounsaturated fatty acids (MUFAs) in fat biosynthesis. Despite being crucial for interpreting SCDs’ roles across species, the evolutionary relationship of SCD proteins across species has yet to be elucidated. This study aims to present this evolutionary relationship based on amino aci...
متن کاملan evolutionary relationship between stearoyl-coa desaturase (scd) protein sequences involved in fatty acid metabolism
background: stearoyl-coa desaturase (scd) is a key enzyme that converts saturated fatty acids (sfas) to monounsaturated fatty acids (mufas) in fat biosynthesis. despite being crucial for interpreting scds’ roles across species, the evolutionary relationship of scd proteins across species has yet to be elucidated. this study aims to present this evolutionary relationship based on amino acid sequ...
متن کاملElucidating the roles of stearoyl-CoA desaturase 1 in adipocyte fatty acid metabolism and cellular function.
Worldwide obesity rates have risen to epidemic proportions, with over 600 million obese individuals across the globe. These individuals are prone to obesity-related health complications, including type 2 diabetes, hypertension, cancer, and cardiovascular disease. Obesity also coincides with the expansion of adipose tissue, which has an important role storing excess calories in the form of triac...
متن کاملRole of stearoyl-CoA desaturase-1 in skeletal muscle function and metabolism.
Stearoyl-CoA desaturase-1 (SCD1) converts saturated fatty acids (SFA) into monounsaturated fatty acids and is necessary for proper liver, adipose tissue, and skeletal muscle lipid metabolism. While there is a wealth of information regarding SCD1 expression in the liver, research on its effect in skeletal muscle is scarce. Furthermore, the majority of information about its role is derived from g...
متن کاملBiochemical and physiological function of stearoyl-CoA desaturase.
A key and highly regulated enzyme that is required for the biosynthesis of monounsaturated fatty acids is stearoyl-CoA desaturase (SCD), which catalyzes the D(9)-cis desaturation of a range of fatty acyl-CoA substrates. The preferred substrates are palmitoyl- and stearoyl-CoA, which are converted into palmitoleoyl- and oleoyl-CoA respectively. Oleate is the most abundant monounsaturated fatty a...
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ژورنال
عنوان ژورنال: International Journal of Molecular Sciences
سال: 2020
ISSN: 1422-0067
DOI: 10.3390/ijms21228619